Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and treatment chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series progressive irreversible physiological changes associated with loss functional, psychological, social capabilities. Numerous factors, such as oxidative stress, inflammation, cellular senescence, geriatric syndrome known frailty, contribute to human body deterioration The speed aging may differ between individuals depending on presence or absence multiple factors (genetic and/or environment) subsequent misbalance homeostasis, together increase which also plays key role developing diseases. In addition, pathological circumstances have been reported precipitate accelerate process. This review investigated mechanisms involved pathologies, particularly kidney disease,